Thank you so much guys for your input. The Flagyl worked for me for years to control pouchitis but I slowly developed more and more bad side effects from the drug. I asked my doctor about Flagyl suppositories but he will not prescribe that since it is not typically used for that. Somebody on the site gave me the idea of trying Flagyl enemas and I’ve had some good early success with that with minimal side effects. I think I would have trouble getting a doctor to go on board with that idea. I’ve tried loperamide and my body just adapt to it quickly.I appreciate your help.