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I have presently taken my second round of cipro and flagyl and while it did stop the bleeding, the bleeding is slowly coming back after stopping Frowner . Has anyone been on these medications for a long time and if so what was the strength level prescribed? Also what other antibiotics are used to treat pouchitis. Whenever I look it up on line, most sites mention only cipro and flagyl, despite reading posts that there are others.... Confused Frowner
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There are many others, augmentin and xifaxin being among them.

I have been on antibiotics for pouchitis for 20 years. Can't get off them. You do need to rotate and cannot stay on cipro and flagyl permanently.

I have taken up to 1000 mg cipro and 1000 mg flagyl a day, but maintainance dosages are usually less. You adjust based on symptomology.

In 20 years of battling pouchitis I never had bleeding. Bleeding is only something I had with UC.
Levacquin (similar to cipro, in the same family of antibiotics), keflex, tinadamax.............there are many others. It is not a question of what is out there but what you can tolerate and what works. Just because there is a med does not mean it will either work and/or be tolerated. It is trial and error and what works well for others might not work for you.

In my opinion the 4 most effective are cipro, flagyl, xifaxin and augmentin/amoxocillin.
I was also told by my Doctor that if antibiotics failed, the last line of treatment is biologics (remicade, 6MP, Humira). But in 20 years, antibiotics, rotated properly, have not failed me. If they ever did, there are the biologics family of meds, and there are multiple biologics including a new one from what I heard. So there are many treatments that are possible.
quote:
What are the symptoms of your pouchitis?


Increased urgency, increased frequency, nightime leakage and spotting, increasing wateriness of schools. No bleeding.

Regarding 5-ASA: It is called Rowasa, Canasa, and Mesalazine in the USA, and Pentasa in capsule form.

http://en.wikipedia.org/wiki/Mesalazine

It is used locally in enemas and suppositories and mostly stays in the gut. Neither the enemas nor suppositories helped me. I could never hold them and if you can't hold them you are not going to benefit. It would also be illogical for me to use such drugs now (enemas or suppositories) because I have inflammation from backwash stool ABOVE the pouch, and the inlet to my pouch is narrowed due to inflammation.

However, I take Pentasa as well as antibiotics, and Pentasa is another derivative of the same drug taken orally as blue capsules. I have taken Pentasa for many years, with antibiotics. These drugs have not been CURATIVE. They keep the pouchitis in a "simmering state", without eliminating it or stamping it out. I have been in "simmer" mode for 20 years. I suppose my J Pouch would have been cooked back in the 1990s without these drugs, so I do not complain.

I have been at this for 20 years with pouchitis, and there are very few things I have not tried (biologics being the main thing, although I was put on Imuran to treat UC in 1991, which was a disaster).
Last edited by CTBarrister

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