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My recollection is it took around 2-3 months for it to reduce inflammation.  In my case, the 8 week intervals for injections were too long based on the level of drug in my system for therapeutic benefit by the end of the 8 week period. My GI is making effort to get insurance approval for six week injection intervals.  I am unaware of any significant side effects from Stelara.  I did notice a reduction with energy level but nothing dramatic.

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