Risk factors for pouch inflammation/complications

Here's the article the previous link was responding to:

http://www.ncbi.nlm.nih.gov/pubmed/22879519

Glad to see this... I chatted with my GI a *lot* after my step 1 surgery about how I wish there was more research concerning pre-operative risk factors for pouch failure (besides "obvious" stuff like CD, advanced age, comorbidities, etc). I have 23 and Me data I can take a look at, but no idea if they show the NOD2 variant in this article. Will have to check later

They do, Liz. You need to type the SNP (rs) number into their general data. If you had it though, it would have come up as a risk for CD and would have been flagged (I know b/c that's how I found out my daughter had one of the three). My daughter's case is complicated by the fact that she's half Indian (me, and these common variants don't exist in the Indian population at ALL) but my brother has UC and half Italian (and they are common there but no IBD other than a first cousin with UC on her dad's side). So, did she get UC through my crappy genes or CD through her dad's? Don't know.
I thought this might help someone decide if they want to skip meds and go to surgery early or go ileo vs jpouch or treat aggressively (which we've decided to if possible based on these results)

Okay, I was wrong Liz, it won't necessarily be flagged by 23andme. I'd assumed it was one of the three main nod2 variants which do get flagged, but I guess it's one with a CD association but a lesser one.
Here's the snpedia link - it lists the risk alleles for CD which I'm assuming is what they're using in the study? Not sure.
http://snpedia.com/index.php/Rs2066847

So, when you're logged into 23andme you can use this link to view your genotype for the SNP: https://www.23andme.com/you/ex.../?snp_name=rs2066847

This is the same as the third Crohn's risk SNP shown on the Crohn's page under Health Results. For what it's worth, I totally don't understand this but it seems like I *don't* have the mutation but my (Crohn's ileitis-having) mother does. I also have a brother who has the same mutation and doesn't have IBD at all.

A couple of the other SNPs mentioned in the article are included on the 23 and me chip but I couldn't find any info about how to interpret the genotypes...