This is my second bout of pouchitis this year. The first bout seemed to go away after six weeks of using cipro, flagyl, and levaquin. That was more than four months ago. When this bout of pouchitis occurred I started cipro and flagyl for 10 days then I got off both to see if it was gone and within a day and a half I felt worse so I got back on Flagyl only and stayed on that for 2 more weeks. I was feeling much better after the two weeks of flagyl although the side effects of flagyl were making me feel nasty in some ways. It has almost been a week since I got off flagyl and I am starting to feel worse and like the pouchitis is not gone. In my history of pouchitis I have only tried cipro, levaquin, and flagyl. I know that many of you have experimented with a lot of different varieties of antibiotics. What would you recommend me to try next? Thanks for any help.