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To all those suffering from chronic pouchitis that is refractory to antibiotics and the standard anti-inflammatory treatment regimen, the drug rebamipide may offer some hope. It has traditionally been used to treat gastritis. Rebamipide has anti-ulcer properties and promotes epithelial cell growth.

Here's a link to the World Journal of Gastroenterology discussing a case study about a patient with severe pouchitis successfully treated with this drug:

http://www.wjgnet.com/1007-9327/12/656.pdf

If you do a web search, there seems to be other encouraging information about this drug out there.

It's obviously too early to know just how helpful this drug could be, but I did want to pass along some information that could offer some hope.

Might be worth talking to our doctors about!

Jon
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I'm actually not sure if it's even approved in the U.S. for anything. The studies they've done with this have primarily been in Japan. I wonder if they have done more studies there since this one. I did email one of the Japanese physicians whose name is on the report, but haven't heard anything back.

It may be beneficial; it just needs to be made available, provided it is safe.

Hi,

I know this topic is way too old but I amcurious about the use of rebamipide in IBD. It is said to help mucosal healing throughout the gastrointestinal tract. I believe it may be used as an adjuvant drug along with regular therapy. I guess it's worth to give it a shot.

Rebamipide is available in a few countries only and India is one of them. Luckily, a friend of mine is India now and she is coming back to Istanbul, Turkey in a week. 

I have antibiotic-refractory pouchitis. I have been on Humira - one injection per week, for three years. Unfortunately, it's not helping much. For this reason, I also take 250 mg Cipro and 250 mg Flagyl once in the mornings. All these just help keep the pouchitis at bay. I still have burning-like pain in the lower left part of my abdomen.

I'll post again when I get Rebamipide tabs and report back my experience.

Erdogan.

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