Hi everyone, I'm the original poster regarding this topic. Just an update...please stay with me. I've had my pouch since 1995. There have been a few bumps in the road over the years, the last one was in 2012. I was sick for months and no one could figure out what was going on. I crashed one night, so much pain, throwing up, and a 103 fever. I spent the next 21 days in the hospital with a spontaneous perforation. I was placed on Remicade, lasted just 2 years before developing antibodies. I didn't start a new biologic and have done fairly well until this summer. Over the summer, I felt like hell, just unwell. I had low-grade fevers and my SED rate shot up from 34 to 57. It dropped to 41, back up to 62, now at 47. The CRP level was also elevated. By the fall, the fevers abated. In November I was hospitalized with a partial obstruction. It was terribly painful, but my pouch still worked during the 5 days, so I thought that was odd. After that cleared with fluids and med, I had an MRenterography three weeks ago which showed nothing, no inflammation, no strictures, no obstructions-nothing., basically no active Crohn's. I still don't feel right. Why in the world is my SED rate 47 and I have tons of pain in my belly and pelvis, also in my lower back. It's deep, burning pain and lots of gurgling. My gastro of 25 years just retired last week, so I have a new guy in his office. My colorectal doc said that SED rates are not that important and that 47 may just be my "new normal". It ran low 30s for the past 5 years. I do have lumbar spine issues, arthritis, joint disease, and disk degeneration. I also had bilateral hip replacements in 2008 and 2012. I know it's a lot to take in, but it's to the point where I just don't want to go to the doctors anymore because it's exhausting. Everything I experience is real and very tiring. So sometimes I just feel like doing nothing which is not a good attitude. But I'm so tired. I'm a 500mg Cirpo and 2000 mg of Pentasa daily. If anyone has the time and interest to help me think this through, I would SO appreciate anything you could do. Thanks, Happy New Year.