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I just wanted to know, for those with fibromyalgia or neuropathies, have you considered the cause may have been some of the meds we are put on for UC, pouchitis, etc.?

Drugs with a known side-effect of neuropathy include:

  • Flagyl (metronidazole)
  • Cipro and Levaquin (flouroquinolones)
  • Sulfasalazine (sulfazine, sulphasalazine)


I was surprised to find out that Sulfasalazine has apparently been linked to neuropathy in a few cases - usually appearing within a few weeks of us.

Also, I read somewhere that steroids enhance the risk of this particular side effect.

Thoughts?
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I've had facial neuropathy / tingling since April. Neurologist knows my history, but said it is caused by anxiety. Currently taking 1 mg of Klonopin and 2 gabopentins daily. I don't buy the diagnosis, but have had head MRI and cat scan done...came back fine. The meds have stopped the tingling, but still not sure what causes it. BTW, when I had my UC, was on all 3 of these meds at times. Surgery to J Pouch was 7 years ago.
I think for those drugs to be implicated, you would need to exhibit some level of neuropathy while taking the drug, not some remote time later. In particular, this is true for antibiotics. With the Azulfidine, it appears that it is a rare side effect, occurring early in treatment, but there is documentation of it occurring with long term treatment. Still, I saw no reports of an association of neuropathy after stopping the drug.

In my case, I am a believer in the neuropathies I have to be a direct result of the inflammatory arthritis and bony joint changes I have developed over time. Reducing the inflammation with my medications has actually slowed the progress of this and I currently have no lasting nerve damage, just irritation from nerve root compression.

I don't know about the steroid connection, but would not be surprised, since it is implicated in all sorts of body system breakdowns with prolonged use.

Jan Smiler
While I still had my colon Cipro gave me c-diff so I can't ever take it again. I have fibromyalgia and peripheral neuropathy in both of my feet plus some other problems. If augmenten doesn't work I use flagyl for pouchitis, because I have the neuropathy but it's not what caused it. We just do it as a precaution just in case it might cause further damage to my feet.

I don't recall taking the third one.

I started out with an under active thyroid, UC, GERD and I have to get the bottom of my esophagus dilated, Fibromyalgia, chronic migraines, arthris, depression,etc.

As far as I know there is no cause for UC and I think the major stressors that brought on my Fibromyalgia was the devil drug Prednisone and my unwillingness to slow down and I worked 60 hour weeks until I couldn't work them anymore.

My local neurologist hasn't figured out the cause of my neuropathy but has also put me on gabepenten that stopped the pins and needles feelings along with the occasional zaps. I just met with a new neurologist at the Mayo clinic about my chronic headaches. After my medication is changed over to fix them he will tackle my feet.

In my own research into peripheral neuropathy it says there are 1,000 potential causes.

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