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Some people find both are necessary, but I’d suggest doing enough testing on yourself to find out if the loperamide is needed all the time. I use Lomotil (which works somewhat like loperamide) at bedtime to get a better night’s sleep. I’ve tried it with and without a number of times to make sure it’s worth taking. Otherwise I only use it if I’m going to be away from a decent bathroom for a while, such as before getting on a boat.

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