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I have been treated for prediabetes aggressively for 15 years-I have terrible insulin resistance and have taken jardiance most recently. My endocrinologist noticed my a1C creeping up (I have normal BMI and I exercise 6 days a week ) she gave me a sample of ozenpic 0.25! I was shocked at day 1 how much better I feel-formed ish stool for the first time in forever? Anyone else on this? What are your experiences I’m curious

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Since gallbladder disease is a major risk after a colectomy, GLP-1 isn't advisable, as it carries a warning of risk of gallbladder disease  and pancreatitis and Ileus (blockage). Blockages and pancreatitis are also a big risk after colectomy. These three things are already known to be far higher risk for j pouchers/ostomates, then, we add in the risks for these same 3 issues that GLP-1 has- and your risks go up exponentially. so you have the J-pouch and the GLP-1 exerting the same risks and it's not a great combo.

I don't know about you, but I can't afford to lose any more of my digestive system, including the risk to my pouch if any of the above occur. I did a ton of research ( I also happen to be a medical research Md.) and was blown away by how risky any of the 'tides would be for a j-poucher. Also, for the record, diabetes and other insulin issues are extremely common after colectomy or can worsen existing issues.

@RenReeves posted:

I don't know about you, but I can't afford to lose any more of my digestive system, including the risk to my pouch if any of the above occur. I did a ton of research ( I also happen to be a medical research Md.) and was blown away by how risky any of the 'tides would be for a j-poucher. Also, for the record, diabetes and other insulin issues are extremely common after colectomy or can worsen existing issues.

Hello, and thank you for this.  What are the 'tides? 

These are drugs like Ozempic and Wegovy. Their side effect profile is widely discussed in reliable sources. Their effects after colectomy are likely to be more speculative, since no studies will have been done in J-pouchers. I’m not sure I agree with the risk estimations posted above, and I sure use the terms “major risk,” “big risk,” and “exponentially” more guardedly, but I treat any new medication with caution.

I am currently taking tirzepatide - the compounded version of Zepbound. I have had moderate success in losing weight and losing inches!  I’m a 25+ year j-poucher and have had major struggles with my weight.  While this drug may not be a miracle, it has shown to be helpful. My primary doc recommended this, and my cardiologist said there are some great benefits for heart function as well as weight loss. I haven’t yet talked with my gastroenterologist. I appreciate the comments and information shared here, and will take it under advisement.

I had my J pouch back in 1989 so it’s been 36 years and I started Ozempic over 3 years ago to help with postmenopausal weight gain that I could not get rid of with diet and exercise.  Not only was I able to lose 30 lbs slowly, over a period of a year, and keep it off, but it did slow down my “rapid transit system”.  Before Ozempic, I was rarely satiated.  I would eat, then everything went through me so quickly and I always felt like I was thinking about food.  Now, I don’t experience “food noise” and eat much less, which is so much better for my J pouch, which is working less.  I am a big fan!!!

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