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Hello everyone!

I'm looking for some advice about taking 300mgs Ibuprofen every 48 to 72 hours. I have avoided it forever but recently took it for a bad headache and occasionally in the past for backache. To my surprise I found I slept through the night without a BM or to urinate. The effects lasted for 24 to 36 hours. Maybe it's a secondary effect or maybe there is minor inflammation in the pouch. In the past I have taken Physlium, Rifaxamin & Cipro but find it has little effect after consquective days use so just put up with going every 2 to 3 hours depending on what I eat. I've asked my Gastro for advice but was interested to hear any thoughts from patients.

I'm 7 years with J pouch after UC, 63 years old & take no other medicines.

Thanks

Paul

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The usual advice is to avoid NSAIDs like ibuprofen. They can irritate the gut and cause ulcerations, particularly with chronic use. In the short term they will reduce inflammation, and I do take one (Celebrex) once or twice a week. Perhaps you can strike a balance, but it’s best to stay alert to the risk.

I was surprised to read that you found the effects of psyllium to wear off fairly quickly. Psyllium works purely mechanically, so unless the gut changes its behavior to completely undo the effect it should continue to work (I’ve been using it for about 19 years with good results). Lomotil and Imodium similarly don’t generally report diminished effect over time, and I use Lomotil at bedtime to help me sleep though the night. The antibiotics do have a tendency to have reduced efficacy over time for many people, though I’ve had very good luck in that department over the years.

You can experiment with ibuprofen, with the understanding that it may cause GI inflammation and/or bleeding, in addition to other effects such as liver inflammation and heart damage.

In my case, I took high dose ibuprofen for years post pouch to help with inflammatory arthritis. It was great at first, but then I developed liver inflammation and that ended it. I did develop chronic pouchitis but that was many years after stopping the NSAIDs.

Jan

LoveLife: Tylenol is not an NSAID. It is an analgesic, which means it alleviates pain. You can do a search to confirm this fact.

Paul: Be very careful if you choose to use NSAIDS. I was using oral NSAIDS for migraines and they caused bleeding ulcers. Years later, was also given IV NSAIDS by mistake by medical professional and got bleeding ulcers again, this time requiring blood transfusions. You might not be as sensitive to them as I.

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