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As Jan said, Stelara targets interleukin 12/23 pathway which mediates inflammation but this pathway is not gut specific and is implicated in other disease processes. Stelara is approved for UC and Crohn’s, but also psoriasis and psoriatic arthritis. It is in clinical trials for a few other rheumatologic diseases, as well. Just wanted to add this, as it is not like vedolizumab which does have a gut specific target (an integrin so totally different mechanism of action). This is important because as Jan said, infection is a risk like many of the biologics other than vedo, but also because there is some chance it may help extraintestinal manifestations of IBD such as arthritis (MAYBE, no trial yet). Anywho. More than you may want to know!

I just started Stelara 6 weeks ago.  I had issues with Remicade, after 10 years started giving my psoriasis.  It took a few weeks but it seems much like Remicade to me.  Hopefully it will eventually get rid of the psoriasis because that is no fun either.  I am hopeful this will continue to work as advertised (literally).

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