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This was my go-to AB when my usual combo (Augmentin and Cipro) started failing after about 10 days.  I would add it to the combo and it would reset things, and I'd take the combo for another 10 days and then repeat the process with Flagyl.

This worked for 10+ years, until about 3 months ago.  

Now I can't seem to get on top of the pouchitis.  I guess Flagyl isn't effective anymore.

Jan Dollar posted:

10-14 days is common. The lowest dose and length of time is best to avoid side effects. If two weeks is not enough you just need to let him know. I currently am on rotating antibiotics and take two week courses of each.

Jan

Jan I thought you were trying the biologics and were not taking antibiotics. Or are you taken them in tandem?

My Dr wants to try some enemas next then maybe 6mp or treatments of that sort. Then Remicade. I feel he is just going to try and shotgun my problem. What is the usual course of treatment options before they throw up their hands and reverse the pouch (which I've heard has its issues as well) 

Ive always been proactive in my care and I'm at a loss for finding any reliable info.

The previous post was from April. I had not yet begun Remicade. I just finished my Remicade induction and will have my first maintenace infusion in August. I continued the antibiotic rotation during induction, and just stopped taking them yesterday. So we will see if I can stay off of them.

I think they just move up the ladder on treatments and it is pretty much up to you whether you want to try them, live with the dysfunctional pouch, or have it removed. 

For me, using Imuran (pretty much the same as 6MP) was not considered to specifically treat pouchitis, but as part of the Remicade treatment. It is low dose and serves two purposes. One is to enhance the effect of Remicade in suppressing inflammation. The other is to reduce the risk of anti-Remicade antibody formation.

Jan  

Jan Dollar posted:

The previous post was from April. I had not yet begun Remicade. I just finished my Remicade induction and will have my first maintenace infusion in August. I continued the antibiotic rotation during induction, and just stopped taking them yesterday. So we will see if I can stay off of them.

I think they just move up the ladder on treatments and it is pretty much up to you whether you want to try them, live with the dysfunctional pouch, or have it removed. 

For me, using Imuran (pretty much the same as 6MP) was not considered to specifically treat pouchitis, but as part of the Remicade treatment. It is low dose and serves two purposes. One is to enhance the effect of Remicade in suppressing inflammation. The other is to reduce the risk of anti-Remicade antibody formation.

Jan  

Thank you Jan. Just don't know what too do. I haven't tried antibiotic rotation. Just had me on long term Cipro. Which I felt didn't work. 

Thank you I will be looking forward to hearing how you progress.

Did you know flagyl is also given to dogs that have diarrhea? My father's Shih Tzu came down with diarrhea last week and the Vet gave her a med which seemed to shut it down immediately. My father told me the name of the med was not pronounceable but was liquid drops he was sprinkling on the dog's food and she was then eating it. I walked next door to his condo this morning to examine the bottle, and sure enough the Vet gave her good old Metronidazole aka Flagyl liquid drops!

Last edited by CTBarrister

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