Having had pouchitis pretty much non-stop for the past 15 years, I think the efficacy of my Cipro/Augmentin/Flagyl combo is starting to wane. My maintenance drugs were a combo of Cipro/Augmentin for years (I've been on them daily) , and I enjoyed about 14 days or "normality" at a time before I had to add in some Flagyl in for a couple days to reset things back to normal. Then it was another enjoyable 14 days. This rinse and repeat process lasted about 10 years, and then I noticed the antibiotic powers starting to wane.
My normality time period then became about 10 days at a time, and then it was back to adding in some Flagyl to reset things. This lasted another three years I'd estimate.
The last two years, the success of those three drugs has been a toss-up each week. I've thrown in some Xifaxan here and there try and shake things up, but I've had limited success with that drug. I haven't tried adding in Tinidazole yet and i haven't tried the enema route (not a big fan of enemas, but I think I'm at that point where I'd be willing to give them a shot) so I guess there are a few more options to try before going the infusion route.
Is there a good list of antibiotics posted here that folks have used to keep pouchitis at bay? Are any of them as common as Cipro/Augmentin/Flagyl where an insurance would easily cover them? Xifaxan is expensive with my insurance, for example.