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I had my esophagus dilated yesterday. Doc wants me on a Proton Pump Inhibitor (PPI) for 3 months to protect it from acid. I know PPIs and H-2 blockers disrupt gut bacteria which makes serotonin in the gut, causing some people to get depression. I already deal with Seasonal Affective Disorder and don't want anything else to make it worse.

If 95% of serotonin is made in the gut, but we don't have a "gut" anymore, does that mean that these drugs won't affect us? Or do our J Pouches adapt and become places where gut bacteria are living and creating serotonin?

Also, anyone know which is worse for the gut bacteria, PPIs or H-2 blockers?

I need to start taking something ASAP so I don't get a stricture. But I want to take whatever's least likely to add extra depression to my life. PS: I can't take antidepressants. Tried them all. Various side effects and restless leg from them all. So that's not an option for me. Thanks.

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Before my UC diagnosis  my GP either gave me antibiotics or antidepressants as he told me both made up over 75 % of his prescriptions .I listened to him and before my uc diagnosis my sleep,skin,mind were a terrible mess.but nearly a year out from my takedown surgery my skin,mind and sleep have improved  massively. My doctor apologised to me but I don't forgive him for not taking my temperature or checking my tongue.even now he just asks me whatever I need he will prescribe it

I have gone cold Turkey on the 10mg of lexapro I was prescribed  that definitely  helped the jpouch journey.

the light headedness is amazing but was told it should last 3 weeks.but healthy guts equal healthy skin,mind and sleep.

@Chook2 posted:

Before my UC diagnosis  my GP either gave me antibiotics or antidepressants as he told me both made up over 75 % of his prescriptions .I listened to him and before my uc diagnosis my sleep,skin,mind were a terrible mess.but nearly a year out from my takedown surgery my skin,mind and sleep have improved  massively. My doctor apologised to me but I don't forgive him for not taking my temperature or checking my tongue.even now he just asks me whatever I need he will prescribe it

I have gone cold Turkey on the 10mg of lexapro I was prescribed  that definitely  helped the jpouch journey.

the light headedness is amazing but was told it should last 3 weeks.but healthy guts equal healthy skin,mind and sleep.

Your lucky, doctors barely apologize

@tulsamom posted:

Totally. Is that what you got from the articles? That the serotonin in the guy doesn't go to the brain it affect the brain at all? They were pretty complicated and not studies specific to that question. More related to IBS and different levels of a functioning pouch. But I was glad to see that out pouches do adapt to make serotonin.

Yeah the human can adapt to anything, that is what makes us different from trees.

@tulsamom posted:

Thanks for the story Chook.

Does anybody have an answer to my question? Does our J pouch start to create serotonin like the guts that we no longer have? I’m talking natural serotonin not from a pill. Thanks again!

Serotonin is produced by Enterochromaffin cells (EC), among other cell types, in the gut including in your small intestine. Bacteria don’t make the serotonin in your gut though the interaction between microbes and the ECs are important to their function. ECs can be stimulated to produce serotonin by a number of signals like mechanical stress, microbes, the content of your meal (e.g glucose). The serotonin produced acts locally in your enteric (gut) nervous system to regulate peristalsis, inflammation, etc. This serotonin does not act on your brain. There are a number of other signaling molecules/hormones in the gut but serotonin is a major one.  It’s a very complex and impressive system though as we all know here, much can go awry.  The short version. You still have ECs in your small intestine cranking out serotonin. Your pouch doesn’t need to “learn to make it”. But again that has no bearing in levels in your brain.

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