Does anyone take cholestyramine that has cuffits? I feel that a hour or so after taking my dose that my cuffitis symptoms go into overdrive. My doctor thinks I'm imagining it.
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One way to find out for sure is to stop it for a few days and see if the symptoms resolve. I suppose an inactive ingredient could be causing irritation. Maybe a different brand or formulation would work better, like Cholestid pills.
Jan 
My local GI said he'd rather I not use it because it binds things so much it might hinder the medications I take such as for my thyroid and antidepressants. I have chronic cuffitis and thought it would help it by neutralizing some of the acidity flowing through.
I don't like your doctor's attitude! You are the one experiencing the reaction not your doctor. If you are not benefiting from using it then stop using it. I haven't seen much discussion about it's use in this support group therefore doubt it is used much. I relied on Metamucil and digestive enzymes for over a year after my take down until my plumbing got use to the added acidity because we no longer have colons.