I know it is too late for many here but,it might save one colon.
I am driven to solve the disease.
Hopefully I will get it close someday.
Old Mike-AKA Glenns Dad
Here is the whole thread from another forum,what I have posted here are mostly studies.
http://www.healingwell.com/com....aspx?f=38&m=2834542
Based on Dysbiosis in inflammatory bowel diseases: the oxygen hypothesis.
The key point I believe is that facultative anaerobes should not be present in any kind of high amounts.
Seems like this is tying together.
Inflammation, generates more oxygen in the colon iNOS/possible excess nitrates in diet/ROS/blood, all add to excess oxygen , or oxygen radicals. Obligate anaerobes/bacteriodes die, trpsin/protease is not deactivated,facultative anaerobes grow and invade,more inflammation,tissue destruction. Not necessarily in this exact order.
Interestingly enough bacteriodes are the only bacteria known to deactivate trypsin, a serine protease.
If too much protease is present say in the colon/rectum we start to digest ourselves.
Possible trigger events.
Antibiotics
excess nitrate in diet
infection
pesticides
Believe need a multipronged approach.
Low nitrate/nitrite diet. May need to go totally organic,and stop certain veggies.
Possible low arginine diet/reduced arginine.
Manganese
Perhaps DMSO or other oxygen scavenger that works in the colon.
Might even need pred to first stop the inflammation, as much as possible.
Certain probiotics may help,don't know which ones.
Probably much more one can do,need to put more thought into it.
This might be why they can't find a specific IBD pathogen,and why it is idiopathic.
Its our own bacteria.
Please read all this info so you can understand what is going on.
http://www.ncbi.nlm.nih.gov/pubmed/23677008
inflammation probably causing the problem
http://www.ncbi.nlm.nih.gov/pubmed/23478337
levels in ibd
http://www.ncbi.nlm.nih.gov/pubmed/7481547
host derived nitrate.
http://www.ncbi.nlm.nih.gov/pubmed/23393266
well what do you know,brings us full circle back to inos.
http://www.sciencedaily.com/re.../02/130207172102.htm
inhibitors
HtWUa6ZCuQJ:www.mdpi.com/1420-3049/17/7/8118/pdf+&cd=7&hl=en&ct=clnk&gl=us" target="_blank">http://webcache.googleusercont...&hl=en&ct=clnk&gl=us
arginase
http://www.healingwell.com/com....aspx?f=38&m=2607313
more
http://www.jimmunol.org/content/173/3/2109.full.pdf
You would want to be Manganese sufficient.
more bacteria are NO generators
http://onlinelibrary.wiley.com...36.2008.03612.x/full
diversion colitis
http://link.springer.com/artic...1018885217154#page-1
counter point
http://onlinelibrary.wiley.com...2/ibd.3780050115/pdf
NO from dysbiotic respiration of nitrate
http://onlinelibrary.wiley.com...036.2008.03612.x/pdf
Nitrates in diet
http://ajcn.nutrition.org/content/90/1/1.full.pdf
http://www.nutritionj.com/content/8/1/16
http://www.inchem.org/document.../jecmono/v50je07.htm
Moving on to nitrates and nitrite my old thread,more info.
http://www.healingwell.com/com....aspx?f=38&m=2503059
Oxygen scavengers
DMSO
http://www.ncbi.nlm.nih.gov/pubmed/8493453
and UC dmso
http://www.ncbi.nlm.nih.gov/pubmed/1350610
free radicals old stuff,takes some time to load
http://gut.bmj.com/content/34/7/865.full.pdf
trypsin and bacteria
http://www.ncbi.nlm.nih.gov/pubmed/23840402
http://www.ncbi.nlm.nih.gov/pubmed/21073731
I am always harping on protease.
http://en.wikipedia.org/wiki/Trypsin
Something might be going on with certain probiotics
http://www.sciencedirect.com/s...ii/S0891584906004229
some NO chemistry
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782592/
inos mucus
not sure what this might mean, brand new info
http://www.ncbi.nlm.nih.gov/pubmed/23977158
another on dysbiosis
http://archive.ispub.com/journ...sthash.uC9lL8Q3.dpbs
selenium
http://link.springer.com/conte....1007/BF02034441.pdf
http://www.degruyter.com/view/....067/bc.2003.067.xml
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277928/
Se with milk thistle and vitamin E .For reference
Larry Smarr video on gut bugs
http://lsmarr.calit2.net/multimedia?vid=2EMzInPwDDQ
AHR real important stuff-thread
http://www.healingwell.com/com...6&g=2818976#m2818976
have to look at this one carefully
http://www.ncbi.nlm.nih.gov/pubmed/23093385
mucosa associated ecoli counts and
http://www.ncbi.nlm.nih.gov/pubmed/23989750
NO and diet
http://www.ncbi.nlm.nih.gov/pubmed/9171946
http://www.pnas.org/content/107/41/17716.abstract
tryptophan not sure what is going on here have to read
http://www.ncbi.nlm.nih.gov/pubmed/23794341
interesting no article,believe his anti-inflammatory diet is full of crap but rest is ok
http://thyroidbook.com/blog/ni...-autoimmune-disease/
to lower NO might need to do the following,perhaps impossible diet
low nitrate/nitrate=organic veggies might be enough not sure,low spinach/celery
low citrulline=no watermelon at least it may also be in other veggies
low arginine and orthinine=low protein
Such a diet might be dangerous, really have to look into what can be eaten.
veggie diet interesting,just a normal veggie diet
http://www.karger.com/Article/Abstract/171451
NO and Sulfide
http://onlinelibrary.wiley.com...36.2008.03612.x/full
more nitrate
http://hes.wfu.edu/assets/mill...0RESEARCH%202012.pdf
arginine NO mild colitis experiment
http://informahealthcare.com/d...3152?journalCode=gas
more
http://www.ncbi.nlm.nih.gov/pm...6/pdf/v049p00387.pdf
crohns gut bug types
http://www.obgynnews.com/news/...3ca53b49a3d3867.html
Follow up info.
http://archive.ispub.com/journ...9lL8Q3.TglVgq8e.dpbs
More new info on dysbiosis in UC. Seems to be a strict anaerobe.
Looks like they are killed off,NO at it again I suspect.
Interesting they say ONSET.
"Bacteria play an important role in the onset and perpetuation of intestinal inflammation in inflammatory bowel disease (IBD). "
Resistant starch has got to help.
This is perhaps why lacto bacteria helps some people,cross feeding =metabolites from one set of bacteria
feeding others like Faecalibacterium prausnitzii
Seems like we need to eat for our gut ecology,and not just what we like,also might want to cut down on fat.
Might also suggest some citrus fruit with each meal,whole fruit with pulp,or at least juice with pulp.
http://www.ncbi.nlm.nih.gov/pubmed/24021287
http://www.ncbi.nlm.nih.gov/pubmed/12361264
most abundant in normals and missing in us Faecalibacterium prausnitzii
http://www.ncbi.nlm.nih.gov/pubmed/23831042
trying to figure out where they come from
http://www.ncbi.nlm.nih.gov/pubmed/23351032
lots of bad actors also
http://en.wikipedia.org/wiki/Clostridium
guessing soils
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123838/
read
http://jmm.sgmjournals.org/content/59/2/141.full
whole grains can increase also bitter melon and yams,not sure how good whole grains are for UC people
http://www.motherjones.com/env...a-weight-loss?page=3
not sure what this says but it might seem we need to eat fiber fiber fiber/RS/RS/RS resistant starch
of course this = gas gas gas but this is a way to increase Faecalibacterium prausnitzii
http://www.ncbi.nlm.nih.gov/pubmed/20346190
http://www.ncbi.nlm.nih.gov/pubmed/21952691
slow process
http://www.ncbi.nlm.nih.gov/pubmed/10673915
Post Edited (Old Mike) : 9/12/2013 12:12:57 PM (GMT-6)
Perhaps a clue as to why vegetarians might get UC.
http://www.ncbi.nlm.nih.gov/pubmed/22182464
uc
http://www.ncbi.nlm.nih.gov/pubmed/22092917
real good article on what happened to our food
http://www.nytimes.com/2007/01...?pagewanted=all&_r=0
Original Post