Yes it dissipates after a couple coffees within the first hour or so of waking but I never quite feel 100%. Its just enough to zap my drive to workout like I used to. There is a temptation to hit the caffeine hard to compensate but the anxiety keeps that in check. Sometimes I wake and almost dream of the times of feeling refreshed upon waking pre colitis. I can't even remember how I felt pre pouch bit I think I felt better upon waking even with my colitis colon still, although that was likely only a matrer of time as well.