I take a maximal dose of the very similar VSL #3 DS (4 packets per day). Since I’m also on antibiotics the timing was tricky. I experimented with once per day dosing (of Cipro and Flagyl) and it seemed to work as well as split dosing, so I take my probiotic at breakfast and dinner, and my antibiotic at bedtime. Maybe ask your doctor if less frequent antibiotic dosing would be okay?