My doctors also pushed biologics first for the same reasons, and because they believed them to be safe. I was put on Entocort before biologics but that was at my request. I can understand your concerns. You don't know about side effects until you try them. Nothing ventured nothing gained, or lost. Ultimately they may be your best option, but I agree with JJA that you might want to try Entocort/Budesonide first.