Hi - I’ve had the pouch since 2010 with chronic pouchitis and tenesmus. My doc and I went off use with Ativan .5 - and that does seem to help . She wrote for .5 3x a day but I don’t need unless really bad. I have made myself rso oil (Rick Simpson oil) cannabis suppositories / I tried to get the highest cbd content but the rso oil is a special blend used to treat cancer with higher doses. I use cocoa butter and the rso oil - heat them up and mold into suppositories and use as little as possible a dose because I don’t want the high. This relaxes the entire area better than any pharmaceutical and I m not running to bathroom - at a small dose applied directly to rectum - seems to really work for me where pharmaceuticals have failed me for the past 40 years. (I’ve had UC since age 10 a had everything and they either have horrible side effects, make symptoms worse or stop working after a while. I’m trying everything I can to stay out of hospitals. I got a bidet that cleans and dries area and watch diet and timing of food closely. Good luck / this is a painful condition. I am still able to work at a high level of thought with the rso suppositories. hope this helps in your research. Regular docs won’t know much about cannabis so do your research - my doc said - please try it and tell me if it works ! Lol