Hi there, Athena! I looked up the Digestive Advantage and found there were several kinds. One is particularly marked for digestion. Which did/do you take? And what does cuffitis feel like? I often wonder whether my butt discomfort is hemorrhoids, cuffitis, or something else? It seems I get a variety of butt aches which come and go randomly. I have 1,000,000 types of butt ointments, creams, pastes, etc., and I just keep trying one after another until something helps. It's different on any given day. The worst is when nothing helps! The best is when the butthole takes a break from being irritated. What a persnickety butthole!