If it were me, I would do one thing at a time. Try reducing the loperamide 1pill at a time. If that is not adequate, reduce the Metamucil gradually. Since you are prone to fissures, you probably need to stay on some Metamucil.
If you think you ahve bacterial overgrowth, you may want to try Cipro, with or without the Flagyl.
Good luck.
Jan