How many doses of the antibiotics have you taken and what dose? Have you ever had pouchitis? If it is pouchitis, then being sick for 10 days is not the same as being sick for a day or two, meaning the antibiotic may take longer to take effect. I personally feel the antibiotics working within 12-24 hours, but if I've been sick and dehydrated, then sometimes 48 hours, but I know it is working., and the effect is gradual. I hope you start to feel better soon.