Never had a problem with sleeplessness from Remicade. I always get a Benedryl with my infusion that that knocks me out. My husband has always averaged about 5 hours of sleep per night - he started taking 1/2 dose of melatonin (per our daughter who is a Registered Dietitian) and is sleeping much better. I've been on Remicade for 6 years, and didn't have any side effects for a long time.