I also had a elevated WBC recently, but it was after I went off rifaximin (generic of xifaxan, but cheaper) for 6 weeks. This last 15 months the pouchitis had never really gone away. I would rotate antibiotics every month and would be on them 2 weeks of every month. While on the antibiotics for the 2 weeks each month, I went off the rifaximin. Then I decided not to go back on rifaximin since I didn't think the rifaximin was really working for pouchitis. I was quite surprised during a routine blood test to find out the wbc was triple from the last test (3 months earlier) So i guess it kept the wbc normal.
I have now started entivyo (no more rifaximin for now) and will be curious to see my next blood test results. I have only been on entivyo for 1 month (2 doses so far). Can't really tell if it's working (supposedly takes 8 weeks) Time will tell, there are good and bad days.
I have had my k-pouch for 18 years.