Hey Scott, thanks for the reply and info. I guess my theory was off regarding pouchers vs. non-pouchers! I've had pouchitis several times over the years, but luckily it hasn't been a huge problem for me, so I don't need anything that strong. The 50 billion culture pills upset my stomach, gave me gas and caused me to go more than usual. My main goal with the probiotics is to prevent, as best I can, I the onset of pouchitis. I bought the probiotics from CVS, so I guess I'll look for some with a lower dose. I think I saw some that were 20 billion, so maybe I'll give those a try.