Cuffitis, which is essentially UC of the remaining bit of colon, is more typically treated with mesalamine than antibiotics. Canasa suppositories are one fairly easy way to use mesalamine. It can take a while to work, but sometimes works well. As SteveG wrote, though, when one antibiotic fails then adding another can do the trick. When Cipro failed for me adding Flagyl worked (and the combination has worked well for at least 8 years), even though Flagyl alone never helped me.