This post is 3 years old but I am so grateful to see it. Thank you - all of you - especially @sldrx I hope by now someone has done the research needed to publish a paper on this topic.
Last week, after years of being sadder than sad, I agreed to try an antidepressant. I tried one in 2015 but my G/I system couldn't handle it. My doc is aware that SSRIs have an impact on gut motility, so he prescribed a micro dose of Zoloft to start - only 12.5 mg once daily. I did my level best to tolerate the unrelenting diarrhea, the new stomach pain and nausea to the point of retching. My mood did lift, but after 8 days and the loss of 5 pounds, I had to send up the white flag and call it quits. My doc agreed, Zoloft isn't gonna work for me. After it clears out of my system, he wants me to try Lexapro, but at this point I think I might be better off staying away from SSRIs altogether. I need the jpouch to keep working - I don't want to put any stress on it. Thoughts?