Pretty much none. My quality of life is very good. Very occasionally at the end of a cycle before my next Remicade infusion I will get a tad more frequent with the BMs, but nothing major. I am a trial attorney and I am in Court all the time. I have functioned as such for 27 years. I got my J Pouch the same year I started practicing law. My symptoms are I feel under much better control now than in the 1990s. Remicade didn’t exist in the 1990s. In fact, none of the biological drugs existed except Imuran, which is harsher on liver function than all the others. For that reason I flopped on Imuran. In the 1990s you basically either responded to antibiotics or else you lost your Pouch eventually. I managed to survive with it. But it’s much better now.
Like I said though I am very lucky and seem to tolerate antibiotics and Remicade and other meds better than some other people.