Reply to "Potential Cancer risk in the Cuff area of the J-Pouch?"

CTBarristerMember

I have my cuff biopsied annually despite having had little to no inflammation there because I am in 2 of the 3 "high risk" groups, for all of which annual scoping and biopsies is indicated:

1. Dysplasia of the colon pre-colectomy;

2. Chronic inflammation of the Pouch;

3. Cancer of the colon.

If you aren't in one of the stated risk groups the recommended interval could vary from 1 to 5 years, and you have to decide how much risk you want to take.

The Cleveland Clinic did a study on pouch cancers around 10 years ago. While they are rare, the risk isn't zero. My recollection is the study showed most cancers started in the cuff and occurred with patients who had severe and poorly treated pouchitis. My former GI Dr. O was somehow involved in that study when he and Dr. Shen we're both still at CC. He knew many of the patients who were in the study as I recall.

9/15/212:53 PM

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