Reply to "Positive Results from Remicade?"

Before we go off the deep end worrying about Remicade and cancer risk, we need to look at the facts, not just perceptions. Recent long term studies have shown that there is no increased risk of solid cancer rates (like colon, lung, or breast cancer) in those who take biologics, such as Remicade. Just because someone gets cancer while taking these drugs, it does not mean there is a cause and effect, paticularly since most of these cancers take many years to develop. Here is a link to an article discussing it:
http://www.rheumatology.org/ab...tnf_cancer_risks.asp

That does not mean the biologics are not without risk. Mainly, it is bone marrow supression and liver damage. That is the reason for frequent monitoring blood tests. Typically, these issues are reversable when you discontinue the drug.

My main issue with Remicade is the higher risk for allergic reactions, mostly because of the mouse protein it is based on. I was happy when my rheumatologist suggested Humira without even trying Remicade. Humira is human protein based, and also does not need an office visit for IV infusion, since it is given by injection. I prefer self administration, as it is less disruptive to my life. I have been on biologics for over 7 years. First Enbrel, then Humira, and now Simponi. During that time, I have only had improved arthritis symptoms, and my gastroenterologist says my pouch has never looked better. I have my labs checked every three months and have only improved over the years (liver inflammation that was present at the beginning of treatment has only improved).

Bottom line, biologics are great to avoid long term steroids. But, obviously, you should not take them if they are not necessary. Just do your homework and make an informed decision.

Jan