Chronic pouchitis here for over 10 years. I used PB tablets in rotation with my other antibiotics early on. It worked amazingly well. I didn't know enough about rotating my meds early on and stayed on for several months instead of weeks. I had zero side effects, but it just stopped working (similar to other antibiotics that I stayed on too long). My combo now is 3 weeks on, few days off, and switch antibiotics (Flagyl, Alinia, Xifaxan).