I have had continued success using Oil of Oregano. At first I took one capsule x 2 per day and in recent weeks take it only once per day. I had terrible luck filling my own capsules as it would leak and burn upon any skin it touched. I have been using -prefilled capsules sold at our local health food store. Once in a while I will feel like pouchitis may be "knocking at the door" and when that happens I'll take a Cipro or if needed take another dose 12 hours later. I've been basically Cipro and pouchitis free for the past 4 months. This is after having chronic pouchitis for years.