to deal with my pouchitis/s.i.b.o. i take one antibiotic at a time try to make a few to 3 weeks then rotate to another...never needed two at a time yet o in all these years and with my dcd diet i have been able to get by on 1/2 the dosage except for xifaxin which i tale 600 mil twice a day..but before diet could never take xifaxin it never worked..