The alcohol/Flagyl reaction is poorly documented, but since Flagyl is chemically similar to Antabuse, there is an abundance of caution. I initially refrained from alcohol when I was first prescribed Flagyl, but when I was taking it more often and for longer periods, I became less compliant. After reading some of the literature, I decided to experiment. First with a small glass of wine, then a full glass, then cocktails. There was no reaction for me, even shortly after taking a Flagyl dose. I have my liver enzymes checked every three months and they are fine, actually, better than a decade ago.
I imagine that just like any other side effect, it is individual. If you do choose to experiment, do it at home with small quantities at first. There have been some here who reported reactions from mild nausea to projectile vomiting. Of course, there are also those who get severe nausea with Flagyl use without alcohol consumption.
Jan 