It's sorta the same thing but it only targets the gut. Less to no side effects. You need to fail one or the other before insurance will pay for this. I've been on it 6 months now. I could not tolerate Remicade Yes it's a infusion every 4 or 8 weeks depending how you do. I'm on a every 8 week schedule. Also the infusion is about 1/2 hour. I wish this was around 20 years ago. Maybe I'd still have my colon. But at least it's saving my pouch.