Reply to "new humira antibodies significance?"

Jan DollarModerator, RN, retired

No, it is not an indication of more disease activity. The antibodies are specific to the drug. It means that you need higher doses for the same effect, and it may mean that more and more antibodies will form in response. Essentially, you will need to switch to something else. I didn't even have antibody titers done, but knew it was time to move on when symptoms crept back. I've gone from Enbrel to Humira to Simponi to Cimzia.

But that does not mean that there cannot be new disease activity because of the loss of effectiveness.

There is always something new to try and they seem to get better with each new generation of drug.

Jan

4/27/155:10 PM

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