I've had my jpouch for about 2 years now and I suspect I've had pouchitis for about that long as well, though I wasn't diagnosed until about a year ago. We tried antibiotics and they worked up until I was taken off of them. My doctor then put me on vsl#3 but it actually made things much worse. I stopped use of the vsl#3 contrary to what my doctor wanted and I felt much better for a time. I haven't had a really bad pouchitis flare up since stopping the vsl, but every time I start feeling better... it doesn't last long. I'm running out of patience and I can't keep up with all the positive thinking anymore. I've changed my diet numerous times, I've tried being more active, less active. I've changed my entire life multiple times to no avail. I spend so much time in the bathroom these days that I've developed a severe hemorrhoid which constantly needing to use the restroom has perpetuated the existence of. Does anyone have any experience with a case like this?