Although cannabis isn’t by any means a substitute for conventional treatments for pouchitis, based on my own experience it can certainly address sleep issues and reduce frequency as it has done for @Adam21. Edibles have been more helpful for me than other delivery methods. My medical team is fine with this. (The suggestion to use a powerful class of pharmaceuticals like biologics is unhelpful and misses the point of this thread.) The one thing to be aware of is that cannabis can affect how your body responds to anesthesia, so use of cannabis should be ceased before medical procedures and definitely let the anesthesiologist know. Good luck @Adam21 and thanks for sharing your thoughts on this!