I have had a jpouch since 2007 and a constant battle with pouchitis! Cipro has done major damage to me! I have had tendons blown in both biceps, in both shoulders, also both rotary cuff blown at same time, one total reverse shoulder replacement! I tried it again about 2 months ago after 10 plus years off and after 5 or six days my hip joints were inflamed so bad I could barely walk! After a week off I returned to normal! Flagyl would make my hands freeze up after being on it for awhile! I am now on Remicade after doing Stelara and Entivyo! Going from one infection { Sibo} after another and getting gun shy of antibiotics! So very tired of this constant war but as we all know { it doesn't matter how tired you are of it!} I was diagnosed with UC and when I got horribly sick the last time, I told them to take my colon out! They said that was the cure so I was excited that the hell would end! Then pouchitis hit and they said " Oppps!!!! You must have Chrohn's!!! I have dealt with this hell for 25 years and still have non stop diarihia! What a joy!