I have been on continuous rotating antibiotics for 24 years. I added Remicade in the last 4 years and reduced my antibiotic dosages by over 50%. The key is to not stay on any one antibiotic and rotate them every 2 weeks or so. I currently rotate cipro, flagyl, tinidizole and augmentin. Xifaxin is another good one if your insurance will cover it, as it is not systemically absorbed.