I have struggled with Chronic Pouchitis since having the J Pouch surgery 10 years ago. I take Visbiome twice a day, and Pepto Bismol 2 tablets twice a day. I use Cipro (as I found Xifaxan mostly ineffective), but only when symptoms really get out of control. When I'm on Cipro, I feel great. I would stay on it permanently, but I'm scared to death that I would develop a tolerance to it and it would eventually stop working. I also was told that long term use of Cipro could cause spontaneous tendon rupture. Am I being crazy, should I just take the Cipro permanently and actually feel good? My ultimate fear is pouch failure and having to revert to an ileostomy.