Oh I know how it is! My issue was gas. I had horrific gas straight out of surgery so they thought I had pouchitis. I tried gasx and all that over the counter stuff and nothing helped. Every week I had to add an hour to holding and it was awful if I was cramping or had gas but I tried to hold out since I wanted my pouch to stretch. Bentyl helped a lot, not sure if you are in the US but that could be an option for you. Another one is Levison (sp). Call your doctor though for sure! I had to call mine every week to check in and report.