I am also taking methotrexate and have gotten away with drinking on occasion with it. I am now on 7.5 mg weekly after my liver chemistries spiked a couple months ago and they reduced my dosage from 12.5 mg. I am now back to normal. My liver chemistries were fine on 12.5 for almost 4 years with occasional drinking but then suddenly crept up. My doctor told me 2 drinks a week but some weeks I have none and some weeks 4 or 5. I only have a maximum of one drinking day a week, and on that day I will have a few. Your liver will let you know if it is cool with it or not. Just go for the blood tests regular.