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Reply to "Ischemic Pouchitis? Too many symptoms, Ideas Please"

Looks like the study showed a modest response compared to placebo, but long term the relapse rate was similar to placebo. It is noted that it was specific treatment for F. varium bacteria.  Did you have an antibody titer run for that bacteria, or is your doc using the "shot in the dark" approach? Nothing wrong with that, but just less likely to be effective.

Another thing to consider if this does not work, is a short course of prednisone. Since Pentasa was effective in dealing with the urgency, steroids may help get the ulcers healed. If longer treatment is needed, you can go topical with hydrocortisone suppositories or retention enemas, or oral budesonide (Entocort).

Many countries outside of the US are less likely to prescribe biologics. Perhaps because of the astronomical cost, the cost:benefit ratio just doesn't justify it.

Jan

Last edited by Jan Dollar
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