I do know that i take aleve chronically to treat my headaches as nothing else works. And aleve is an NSAID. And NSAIDS if taken in high doses with a jpouch can lead to pouchitis. For me that would be reoccurring pouchitis which would be a big problem. So that alone right there, unless there is an alternative to aleve, like codeine, then i am out of luck with a j pouch. I just dont see doctors giving me a lot of codeine since its an opioid.