I began taking Humira the end of February. Unfortunately I"m unable to tolerate it as I have developed leg pain in both legs from the glute to the foot as well as severe neuropathy on the left, way less intense on the right. My doctors have recommended Entiviyo as the best option since taking a TNF blocker is out of the question. My insurance company denied the request stating I should try Remicade and Simponi first which are both TNF blockers. Doctors obviously appealing this, but it totally sucks that your health insurance company can over rule a doctor's recommendation. Hoping this gets resolved in a timely fashion.