I would echo what jrws is saying about getting your pouched checked out. 3 months after my takedown I was diagnosed with chronic pouchitis. I've done Cipro/Flagyl and prednisone courses as well as Entyvio. The steroids, cirpo and flagyl only worked short term, the Entyvio did nothing. Life was terrible for a good 1.5 years, I was severely underweight and developed fistulas. My urgency was terrible and I was restless. At that point my diagnosis was changed from indeterminate IBD to Crohn's. At my surgeon and GI's suggestion, I met with Dr. Shen. He has put me on Tinidazole, which is the "next generation" flagyl for long term. I've been on it for 4 months now and have no side effects like I did with regular flagyl. I'm even able to enjoy a few alcoholic drinks while on it, something I couldn't do with flagyl. Dr. Shen also had me do a 30 day course of hyperbaric oxygen therapy to help with the pouchitis and fistulas. This was a big time commitment, luckily my work was fine with me taking off 2 hours/day for six weeks straight. I was also lucky that my insurance covered the whole therapy. Finally, my GI put me on Humira. I've been on it about the same length as the Tinidazole. I went from having 10 - 12 BMs/day and 4 overnight to 4 - 5/day and 1 - 2 overnight. It's worth asking your doctor about Tinidazole and Humira in my opinion. It's improved my quality of life significantly.