Krazy1,
I have a friend who has Crohn's Disease and AS and he is taking Humira, primarily for the AS. He reports very good results. He is however an absolute freak about cleanliness and when I go out to eat with him we have to use one serving spoon and no used utensils can touch his plate.
He says he occasionally feels "wiped out" and others who take biologics report the same.
I believe the Humira is administered by injection.